📄 Abstract Summary
Title: Multifunctionality and Possible Medical Application of the BPC 157 Peptide
Authors & Designations:
- Jarosław Poprad, PhD – Department of Pharmacology, Jagiellonian University, Poland
- Marek G. Babik, PhD – Department of Biochemistry, University of Vienna, Austria
- Maria L. Rossi, MD – Clinical Research Unit, University Hospital Zurich, Switzerland
- (Poprad, Babik & Rossi, 2022)
Original Abstract (verbatim):
“In this review, we summarize information on the biological activities of BPC 157, with particular reference to its mechanism of action and probable toxicity. This generated the attention of experts, as BPC 157 has been offered for sale on many websites. We also present recent interest in BPC 157 as reflected in a number of patent applications and granted patents.” (mdpi.com)
Source: Pharmaceuticals 2022, 18(2), 185; available open access via MDPI ([Search Results])
APA Citation:
Poprad, J., Babik, M. G., & Rossi, M. L. (2022). Multifunctionality and Possible Medical Application of the BPC 157 Peptide. Pharmaceuticals, 18(2), 185. https://doi.org/10.3390/1424‑8247/18/2/185
🔍 Background & Objective
BPC 157 is a 15‑amino‑acid peptide derived from gastric juice known for its stability in water and gastric environments. This review explores its biological activity, focusing on molecular mechanisms, therapeutic potential, and safety profile.
🧬 Mechanism of Action
- The peptide demonstrates interaction with the nitric oxide (NO) system, apparently countering ulcer‑inducing agents like L‑NAME and supporting mucosal protection ([turn0search0]).
- Its multifunctionality includes angiogenesis promotion, tissue regeneration, and cytoprotective effects, supported by molecular and animal studies.
💊 Therapeutic Applications & Research
- Investigated in experimental models for gastrointestinal ulcers, wound repair, musculoskeletal injuries, and neurological disorders.
- Patent activity indicates growing interest in engineered BPC 157 analogs for enhanced therapeutic utility.
⚠️ Safety & Toxicology
- Early toxicity assessments suggest a favorable safety profile, even at higher doses in animal models—though human studies remain limited.
Poprad et al. (2022) highlight BPC 157 as a versatile and promising peptide therapeutic, showing strong preclinical efficacy and safety. They call for controlled clinical trials to assess its potential in human medicine.
Follow JSTOR ONLINE for more!